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The nation's eighth-largest bank, eight Fortune 500 companies, and six of the top 300 U. law firms make their global headquarters in the Pittsburgh area, while RAND, BNY Mellon, Nova, Fed Ex, Bayer and NIOSH have regional bases that helped Pittsburgh become the sixth-best area for U. Michael Bezallion was the first to describe the forks of the Ohio in a 1717 manuscript, and later that year European fur traders established area posts and settlements.During 1753–54, the British hastily built Fort Prince George before a larger French force drove them off.The following year, the Pittsburgh Post-Gazette was started, and in 1787, the Pittsburgh Academy was chartered.Unrest during the Whiskey Rebellion of 1794 resulted in federal troops being sent to the area.Following the American Revolution, the village of Pittsburgh continued to grow.One of its earliest industries was boat building for settlers of the Ohio Country.

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Fort Pitt is notable as the site of an early use of smallpox for biological warfare.It was served by numerous river steamboats, that increased trading traffic on the rivers.In the 1830s, many Welsh people from the Merthyr steelworks immigrated to the city following the aftermath of the Merthyr Rising.-burg) is a city in the Commonwealth of Pennsylvania in the United States, and is the county seat of Allegheny County.As of 2017, a total population of 305,704 lives within the city limits, making it the 63rd-largest city in the U. The metropolitan population of 2,353,045 is the largest in both the Ohio Valley and Appalachia, the second-largest in Pennsylvania (behind Philadelphia), and the 26th-largest in the U. Located at the confluence of the Allegheny, Monongahela, and Ohio rivers, Pittsburgh is known as both "the Steel City" for its more than 300 steel-related businesses, and as the "City of Bridges" for its 446 bridges.

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