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Although the series is set in Seattle (at the fictional Seattle Grace, later known as the Grey-Sloan Memorial Hospital), it is filmed primarily in Los Angeles, California.

The series was designed to be racially diverse and used color-blind casting. Meredith Grey, played by Ellen Pompeo, first featured as an intern.

The title is a play on Gray's Anatomy, a classic human anatomy textbook first published in 1858 in London and written by Henry Gray.

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But where everybody else is speeding up their medical shows, [Rhimes] found a way to slow it down, so you get to know the characters. The idea for the series began when a doctor told me it was incredibly hard to shave her legs in the hospital shower. But then I thought about the fact that it was the only time and place this woman might have to shave her legs.

In its twelfth season, the show had a large ensemble of sixteen actors, including four characters from the original cast (Meredith Grey, Alex Karev, Miranda Bailey, and Richard Webber).

On February 10, 2017, ABC renewed Grey's Anatomy for a fourteenth season, which premiered on September 28, 2017.

"I wanted to create a world in which you felt as if you were watching very real women.

Most of the women I saw on TV didn't seem like people I actually knew. They never got to be nasty or competitive or hungry or angry. " The show's title, Grey's Anatomy, was devised as a play on words: a reference to both Henry Gray's classic English medical textbook, Gray's Anatomy (first published in 1858 and still in print), and the title character Dr. Before the series debuted on March 27, 2005, a few early releases were shown to close friends and family of the producers and actors.

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